Description
MOTS-C Fatigue Explained: Why You Need Carbs and SubQ NAD+ to Max Results
In this episode I break down why MOTS-C often causes fatigue and why it’s a measurable signal of intense cellular remodeling, not that something is “wrong.” I also explain why carbohydrates are non‑negotiable during this adaptation window (kinetics, NAD+/NADH balance, and partial mTOR support) and how daily subQ NAD+ helps maintain NAD+ levels, reduce fatigue, and speed adaptation. I share an 8‑week framework, tapering guidance, and key support supplements.
00:00 Mic Check and Coffee
00:27 What MOTS-C Does
01:36 AMPK Alarm and mTOR Off
03:06 PGC1 Alpha Biogenesis Paradox
05:26 ATP Cost of New Mitochondria
08:06 NAD Plus Crash Explained
14:58 Oxidative Stress Feedback Loop
21:58 Neurotransmitters and Glycogen Drain
25:12 Inflammation and Brain Energy Dip
28:26 Fatigue Timeline and Fix Tease
29:56 Carbs Not Optional
30:33 ATP Kinetics Explained
31:10 Glucose Beats Fat
32:43 ROS And NADH Control
35:11 Glucose Signals mTOR
38:29 Why MOTS Causes Fatigue
41:08 SIRT3 And DNA Repair
42:39 SubQ NAD Plus Fix
44:45 Carbs NAD Plus Synergy
48:44 Eight Week Protocol
51:23 Support Supplements Timing
53:44 Results And Wrap Up
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Dr Trevor Bachmeyer
The Spartan
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