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In this lecture, Professor Zach Murphy breaks down Hepatitis A with a clear, high-yield approach focused on recognition, diagnosis, and management. This video builds a practical framework for understanding how Hepatitis A is transmitted, why it causes acute liver injury, and how to quickly identify it in clinical scenarios.
We begin with epidemiology and transmission, emphasizing the fecal-oral route via contaminated food, water, and close contact. Zach then walks through the pathophysiology, highlighting the immune-mediated hepatocyte injury that leads to the classic two-phase presentation.
Next, the lecture covers clinical presentation, focusing on the progression from a prodrome of fever, fatigue, nausea, and myalgias to the icteric phase with jaundice, dark urine, and right upper quadrant discomfort. You will learn how to recognize the hepatocellular injury pattern on labs and confirm the diagnosis using Hepatitis A serologies.
The session then focuses on diagnostic strategy and management, including when to order imaging to rule out biliary obstruction, how to assess for liver dysfunction, and the principles of supportive care. Special attention is given to identifying patients at risk for acute liver failure and when escalation of care is required.
Finally, Zach reviews prevention, including vaccination, post-exposure prophylaxis, and key public health considerations.
Enjoy the lecture, and please support us below!
Table of Contents:
0:00 Lab
0:51 Etiology, Transmission and Pathophysiology
27:04 Classic Findings of Prodromal Phase
37:20 Classic Findings of Icteric Phase
48:41 Acute Liver Failure
56:00 Diagnostic Approach to Hepatitis A
1:03:34 Prevention of Hepatitis A
1:08:18 Comment, Like, SUBSCRIBE!
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