Description
What is GLP-1 microdosing, and why are more patients asking about it for medications like Ozempic, Wegovy, and Zepbound?
In this episode, registered dietitian Zoe is joined by Deidre, FNP, to explain how microdosing works, why standard manufacturer dosing does not always fit every patient, and how smaller, slower dose increases may help reduce side effects while supporting more gradual, sustainable weight loss.
They discuss why some patients respond strongly to very low doses, why others may need faster adjustments, and how personalized dosing can help patients better manage hunger, cravings, food noise, nausea, and long-term maintenance. They also unpack the recent conversation around pharmaceutical companies, telehealth programs, and microdose marketing.
Most importantly, Zoe and Deidre explain why GLP-1 medications are only one tool. Nutrition, whole foods, protein, fiber, lifestyle changes, and long-term support still matter, especially if the goal is not just losing weight, but keeping it off.
Timestamps:
00:20 - Welcome to the Episode
00:47 - What Is GLP-1 Microdosing?
02:10 - Why Manufacturer Dosing Exists
03:31 - Why One-Size-Fits-All Dosing Does Not Work for Everyone
04:06 - Super Responders, Non-Responders, and Everyone in Between
05:02 - Side Effects from Increasing GLP-1 Doses Too Quickly
06:17 - Why Slower Dosing May Improve Tolerability
07:39 - Why Big Pharma Is Pushing Back on Microdosing
08:00 - Eli Lilly, Noom, and GLP-1 Microdose Marketing
09:19 - Which Patients May Benefit from Microdosing?
10:15 - Gradual Weight Loss and Long-Term Sustainability
11:57 - GLP-1s, Set Point, and Metabolic Adaptation
13:10 - Why Microdosing May Help with Maintenance
14:00 - Why Lifestyle Change Still Matters on GLP-1s
15:27 - Whole Foods, Protein, Fiber, and Hunger Control
17:23 - How Nutrition Supports Better GLP-1 Results
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